Synthesis of acyclic nucleotide analogues derived from 6-(sec- or tert-alkyl)purines via coupling of 6-chloropurine derivatives with organocuprates

被引：15

作者：

Dvoráková, H

Dvorák, D ^{[1
]}

Holy, A

机构：

[1] Prague Inst Chem Technol, Dept Organ Chem, CR-16628 Prague 6, Czech Republic

[2] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-16610 Prague, Czech Republic

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1998年 / 63卷 / 12期

关键词：

acyclic nucleoside phosphonates; phosphonomethoxyalkylpurine derivatives; 6-alkylpurines; purines; organocopper reagents; cross-coupling reactions;

D O I：

10.1135/cccc19982065

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coupling of 9-[2-(diisopropyloxyphosphonylmethoxy)ethyl]-6-chloropurine (23) (and (R)-9-[2-(diisopropyloxyphosphonylmethoxy)propyl]-6-chloropurine (24), respectively) with organocuprates derived from Grignard reagents afforded after deprotection 6-(sec- or tert-alkyl) substituted phosphonates 31-36. As a model a series of 6-(sec- or tert-alkyl)purines 2-12 was also prepared.

引用

页码：2065 / 2074

页数：10

共 19 条

[1]

ANDREI G, UNPUB

[2] REGIOSELECTIVE ADDITION OF GRIGNARD-REAGENTS TO A 2-OXOPURINIUM SALT [J].