Patching up Hedgehog

被引:18
作者
Nusse, R [1 ]
机构
[1] STANFORD UNIV,DEPT DEV BIOL,STANFORD,CA 94305
关键词
D O I
10.1038/384119a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:119 / 120
页数:2
相关论文
共 14 条
[1]   The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal [J].
Alcedo, J ;
Ayzenzon, M ;
VonOhlen, T ;
Noll, M ;
Hooper, JE .
CELL, 1996, 86 (02) :221-232
[2]   A new member of the frizzled family from Drosophila functions as a Wingless receptor [J].
Bhanot, P ;
Brink, M ;
Samos, CH ;
Hsieh, JC ;
Wang, YS ;
Macke, JP ;
Andrew, D ;
Nathans, J ;
Nusse, R .
NATURE, 1996, 382 (6588) :225-230
[3]   DEVELOPMENTAL BIOLOGY - HEDGEHOG DIGS UP AN OLD FRIEND [J].
BLAIR, SS .
NATURE, 1995, 373 (6516) :656-657
[4]   Dual roles for patched in sequestering and transducing hedgehog [J].
Chen, Y ;
Struhl, G .
CELL, 1996, 87 (03) :553-563
[5]   Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome [J].
Hahn, H ;
Wicking, C ;
Zaphiropoulos, PG ;
Gailani, MR ;
Shanley, S ;
Chidambaram, A ;
Vorechovsky, I ;
Holmberg, E ;
Unden, AB ;
Gillies, S ;
Negus, K ;
Smyth, I ;
Pressman, C ;
Leffell, DJ ;
Gerrard, B ;
Goldstein, AM ;
Dean, M ;
Toftgard, R ;
ChenevixTrench, G ;
Wainwright, B ;
Bale, AE .
CELL, 1996, 85 (06) :841-851
[6]   A POTENTIAL CATALYTIC SITE REVEALED BY THE 1.7-ANGSTROM CRYSTAL-STRUCTURE OF THE AMINO-TERMINAL SIGNALING DOMAIN OF SONIC HEDGEHOG [J].
HALL, TMT ;
PORTER, JA ;
BEACHY, PA ;
LEAHY, DJ .
NATURE, 1995, 378 (6553) :212-216
[7]   ROLE OF THE DROSOPHILA PATCHED GENE IN POSITIONAL SIGNALING [J].
INGHAM, PW ;
TAYLOR, AM ;
NAKANO, Y .
NATURE, 1991, 353 (6340) :184-187
[8]   Human homolog of patched, a candidate gene for the basal cell nevus syndrome [J].
Johnson, RL ;
Rothman, AL ;
Xie, JW ;
Goodrich, LV ;
Bare, JW ;
Bonifas, JM ;
Quinn, AG ;
Myers, RM ;
Cox, DR ;
Epstein, EH ;
Scott, MP .
SCIENCE, 1996, 272 (5268) :1668-1671
[9]   Biochemical evidence that Patched is the Hedgehog receptor [J].
Marigo, V ;
Davey, RA ;
Zuo, Y ;
Cunningham, JM ;
Tabin, CJ .
NATURE, 1996, 384 (6605) :176-179
[10]   Cholesterol modification of hedgehog signaling proteins in animal development [J].
Porter, JA ;
Young, KE ;
Beachy, PA .
SCIENCE, 1996, 274 (5285) :255-259