Time-resolved mass spectrometry

被引：42

作者：

Chen, Yu-Chie ^{[1
]}

Urban, Pawel L. ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Dept Appl Chem, Hsinchu, Taiwan

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2013年 / 44卷

关键词：

Biochemical dynamics; Chemical reaction; Fast process; Kinetic measurement; Mass spectrometry; Reaction intermediate; Reaction monitoring; Structural determination; Temporal resolution; Time-resolved mass spectrometry; ELECTROSPRAY-IONIZATION-MASS; ATMOSPHERIC-PRESSURE IONIZATION; ASSISTED LASER DESORPTION/IONIZATION; ION-CYCLOTRON RESONANCE; CHEMICAL-REACTIONS; REAL-TIME; GAS-PHASE; FLASH-PHOTOLYSIS; HADAMARD-TRANSFORM; MICROFLUIDIC REACTOR;

D O I：

10.1016/j.trac.2012.11.010

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Mass spectrometry (MS) offers advantages over conventional spectroscopic assays because it enables structural determination of reactants while preserving temporal resolution. The ability to detect short-lived reaction intermediates or labile metabolites makes time-resolved MS (TRMS) measurements an enabling tool for studies of chemical reactions, chemical kinetics and biochemical dynamics. High temporal resolution requires careful optimization of the interface, which would enable quenching of the chemical process, ionization and rapid transfer of the analytes into the mass analyzer. We review recent advances in TRMS, and outline the prospects for future developments and applications. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：106 / 120

页数：15

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