Homeodomain-containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue

被引：52

作者：

Shrestha, Bishakha ^{[1
]}

Ansari, Khairul I. ^{[1
]}

Bhan, Arunoday ^{[1
]}

Kasiri, Sahba ^{[1
]}

Hussain, Imran ^{[1
]}

Mandal, Subhrangsu S. ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

FEBS JOURNAL | 2012年 / 279卷 / 19期

基金：

美国国家科学基金会;

关键词：

breast cancer; colony formation; gene regulation; HOXB9; tumor growth; HISTONE METHYLASES; GENE-EXPRESSION; ESTROGEN-RECEPTOR; MAMMARY-GLAND; DNA-BINDING; MLL1; DOMAINS; ROLES; VEGF; VIVO;

D O I：

10.1111/j.1742-4658.2012.08733.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HOXB9 is a homeobox-containing gene and is critical for the development of mammary gland and sternum. HOXB9 is also regulated by estrogen and is critical for angiogenesis. We investigated the biochemical roles of HOXB9 and its homeodomain in cell-cycle progression and tumorigenesis. Our studies demonstrated that HOXB9 is overexpressed in breast cancer tissue. HOXB9 overexpression stimulated 3D formation in soft agar assay. HOXB9 binds to the promoters of various tumor growth and angiogenic factors and regulates their expression. The homeodomain of HOXB9 plays crucial roles in transcriptional regulation of tumor growth factors and also in 3D colony formation, indicating crucial roles of the HOXB9 homeodomain in tumorigenesis. Overall, we demonstrated that HOXB9 is a critical regulator of tumor growth factors and is associated with tumorigenesis.

引用

页码：3715 / 3726

页数：12

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