Characterization of the genes encoding a receptor-like histidine kinase and a cognate response regulator from a biphenyl/polychlorobiphenyl-degrading bacterium, Rhodococcus sp. strain M5

被引:51
作者
Labbe, D [1 ]
Garnon, J [1 ]
Lau, PCK [1 ]
机构
[1] NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,MONTREAL,PQ H4P 2R2,CANADA
关键词
D O I
10.1128/jb.179.8.2772-2776.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We report the cloning, sequence, and expression of the bpdS and bpdT genes from Rhodococcus sp. strain MS, which are believed to encode the first two-component signal transduction system in the genus Rhodococcus, which potentially regulates biphenyl/polychlorobiphenyl metabolism in M5. BpdT has a typical responses regulator sequence (209 amino acids; 23 kDa), whereas BpdS, the predicted histidine kinase component, is an unusually large transmembrane protein (1,576 amino acids; 170 kDa) that contains ATP-binding and leucinerich repeat motifs and some conserved residues of protein kinases. Expression of bpdST, like that of the bpdC1C2BADE degradative operon, is inducible by biphenyl.
引用
收藏
页码:2772 / 2776
页数:5
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