The role of macrophages in allograft rejection

被引：131

作者：

Wyburn, KR

Jose, MD

Wu, HL

Atkins, RC

Chadban, SJ

机构：

[1] Royal Prince Alfred Hosp, Dept Transplantat, Sydney, NSW, Australia

[2] Univ Sydney, Sydney, NSW 2006, Australia

[3] Monash Univ, Monash Med Ctr, Dept Nephrol, Melbourne, Vic 3004, Australia

来源：

TRANSPLANTATION | 2005年 / 80卷 / 12期

关键词：

macrophage; allograft; rejection;

D O I：

10.1097/01.tp.0000173903.26886.20

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Macrophage accumulation has long been recognized as a feature of allograft rejection, yet the role of macrophages in rejection remains underappreciated. Macrophages contribute to both the innate and acquired arms of the alloimmune response and thus may be involved in all aspects of acute and chronic allograft rejection. Recent advances in macrophage biology have allowed a better understanding of the mechanisms of macrophage accumulation, their state of activation and the pleuripotent roles they play in allograft rejection. Therapeutic attention to macrophages, in addition to T lymphocytes, may lead to improved outcomes in organ transplantation.

引用

页码：1641 / 1647

页数：7

共 91 条

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