Total synthesis of variolin B

被引：45

作者：

Anderson, RJ ^{[1
]}

Morris, JC ^{[1
]}

机构：

[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 49期

关键词：

D O I：

10.1016/S0040-4039(01)01881-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the marine alkaloid variolin B has been achieved in eight steps, starting from commercially available 4-chloro-2-methylthiopyrimidine. The key reaction involves the tandem deoxygenation and cyclization of a triarylmethanol using a combination of triethylsilane and trifluoroacetic acid. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8697 / 8699

页数：3