Rewiring the Parkinsonian brain

被引：13

作者：

Fricker-Gates, RA ^{[1
]}

Dunnett, SB ^{[1
]}

机构：

[1] Cardiff Univ, Brain Repair Grp, Sch Biosci, Cardiff, S Glam, Wales

来源：

NATURE MEDICINE | 2002年 / 8卷 / 02期

关键词：

D O I：

10.1038/nm0202-105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The demonstration that transplanted embryonic stem cells differentiate into functional dopamine neurons and provide stable functional recovery in a rodent model of Parkinson disease moves the field a step closer to clinical applications of embryonic stem cells.

引用

页码：105 / 106

页数：2

共 11 条

[1]

BJORKLUND L, IN PRESS P NATL ACAD

[2] Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation [J].

Deacon, T ;

Dinsmore, J ;

Costantini, LC ;

Ratliff, J ;

Isacson, O .

EXPERIMENTAL NEUROLOGY, 1998, 149 (01) :28-41

[3] Prospects for new restorative and neuroprotective treatments in Parkinson's disease [J].

Dunnett, SB ;

Björklund, A .

NATURE, 1999, 399 (6738) :A32-A39

[4] Cell therapy in Parkinson's disease -: stop or go? [J].

Dunnett, SB ;

Björklund, A ;

Lindvall, O .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (05) :365-369

[5]

DUNNETT SB, 1994, FUNCTIONAL NEURAL TR, P531

[6] Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells [J].

Lee, SH ;

Lumelsky, N ;

Studer, L ;

Auerbach, JM ;

McKay, RD .

NATURE BIOTECHNOLOGY, 2000, 18 (06) :675-679

[7] Generation of purified neural precursors from embryonic stem cells by lineage selection [J].

Li, M ;

Pevny, L ;

Lovell-Badge, R ;

Smith, A .

CURRENT BIOLOGY, 1998, 8 (17) :971-974

[8] Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines [J].

Ling, ZD ;

Potter, ED ;

Lipton, JW ;

Carvey, PM .

EXPERIMENTAL NEUROLOGY, 1998, 149 (02) :411-423

[9] Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow [J].

Mezey, É ;

Chandross, KJ ;

Harta, G ;

Maki, RA ;

McKercher, SR .

SCIENCE, 2000, 290 (5497) :1779-1782

[10]

PEUBINOFF BE, 2001, NAT BIOTECHNOL, V19, P1134

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