Protective efficacy of Modified Vaccinia virus Ankara in preclinical studies

被引：35

作者：

Volz, Asisa ^{[1
]}

Sutter, Gerd ^{[1
]}

机构：

[1] Univ Munich, Lehrstuhl Virol, Inst Infekt Med & Zoonosen, D-80539 Munich, Germany

来源：

VACCINE | 2013年 / 31卷 / 39期

关键词：

Poxviruses; Recombinant MVA vaccines; Preclinical studies; Vaccine efficacy; T-CELL RESPONSES; SMALLPOX VACCINE; DISEASE PROGRESSION; RHESUS MACAQUES; SHORT-TERM; MVA-B; INFECTION; MICE; IMMUNIZATION; DNA;

D O I：

10.1016/j.vaccine.2013.03.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Modified Vaccinia virus Ankara (MVA) is a tissue culture-derived, highly attenuated strain of vaccinia virus (VACV) exhibiting characteristic defective replication in cells from mammalian hosts. In the 1960s MVA was originally generated as a candidate virus for safer vaccination against smallpox. Now, MVA is widely used in experimental vaccine development targeting important infectious diseases and cancer. Versatile technologies for genetic engineering, large-scale production, and quality control facilitate R&D of recombinant and non-recombinant MVA vaccines matching today's requirements for new biomedical products. Such vaccines are attractive candidates for delivering antigens from pathogens against which no, or no effective vaccine is available, including emerging infections caused by highly pathogenic influenza viruses, chikungunya virus, West Nile virus or zoonotic orthopoxviruses. Other directions are seeking valuable vaccines against highly complex diseases such as AIDS, malaria, and tuberculosis. Here, we highlight examples of MVA candidate vaccines against infectious diseases, and review the efforts made to assess both the efficacy of vaccination and immune correlates of protection in preclinical studies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：4235 / 4240

页数：6

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