In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses

被引：44

作者：

Co, Mary Dawn T. ^{[1
]}

Orphin, Laura ^{[1
]}

Cruz, John ^{[1
]}

Pazoles, Pamela ^{[1
]}

Green, Karin M. ^{[2
]}

Potts, James ^{[1
]}

Leporati, Anita M. ^{[1
]}

Babon, Jenny Aurielle B. ^{[1
]}

Evans, James E. ^{[2
]}

Ennis, Francis A. ^{[1
]}

Terajima, Masanori ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA 01655 USA

[2] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01655 USA

来源：

VACCINE | 2009年 / 27卷 / 02期

基金：

美国国家卫生研究院;

关键词：

T cells; Influenza; Vaccine; PERFORMANCE LIQUID-CHROMATOGRAPHY; LYMPHOCYTE MEMORY; INTERFERON-GAMMA; IMMUNE-RESPONSES; CLINICAL-TRIALS; HUMAN CD8(+); PROTECTION; TRIVALENT; NUCLEOPROTEIN; PROTEINS;

D O I：

10.1016/j.vaccine.2008.09.092

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated three commercial trivalent inactivated vaccines (TIVs) from the 2007-2008 season in terms of their ability to elicit in vitro T cell responses. T cell-mediated immunity may offer a more cross-reactive vaccine approach for the prevention of pandemic or epidemic influenza. Human cytotoxic T cell lines demonstrated differences in matrix protein 1 and nucleocapsid protein recognition of autologous target cells. Peripheral blood mononuclear cells stimulated with each of the TIVs showed statistically significant differences between the vaccines in the numbers of IFN gamma producing cells activated. These data suggest that TIV vaccines are not similar in their ability to activate human T cell responses. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：319 / 327

页数：9

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