A comprehensive karyotypic analysis on a newly established sarcomatoid hepatocellular carcinoma cell line SH-J1 by comparative genomic hybridization and chromosome painting

被引：34

作者：

Kim, DG

Park, SY

Kim, H

Chun, YH

Moon, WS

Park, SH ^{[1
]}

机构：

[1] Korea Univ, Coll Med, Dept Anat, Inst Human Genet, Seoul 136701, South Korea

[2] Chonbuk Natl Univ, Sch Med, Dept Internal Med, Res Inst Clin Med, Chonju, South Korea

[3] Chonbuk Natl Univ, Sch Med, Dept Anat Pathol, Chonju, South Korea

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 132卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(01)00543-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We first established a sarcomatoid hepatocellular carcinoma cell line, designated as SH-J1, and applied comparative genomic hybridization and fluorescence in situ hybridization (FISH) with chromosome painting probes for the characterization of the chromosomal rearrangements. In the SH-J1 cell line, the pleomorphic spindle cells were arranged in bundles of interlacing patterns and were positive in immunohistochemical staining with hepatocyte-related markers. By G-banding and FISH, the chromosomal gains were detected at 6p and 17, whereas losses were observed at 3p21similar topter, 3q27similar toqter, 4, 6q, 13ptersimilar toq11, 16, 18, 19p13, and Y. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：120 / 124

页数：5

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