Altered mossy fiber distributions in adult Fmr1 (FVB) knockout mice

被引:50
作者
Ivanco, TL [1 ]
Greenough, WT
机构
[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Psychol, Urbana, IL 61801 USA
[3] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA
[4] Univ Illinois, Dept Psychiat, Urbana, IL 61801 USA
[5] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA
关键词
hippocampus; dentate gyrus; fragile-X mental retardation syndrome; development; axon;
D O I
10.1002/hipo.10004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The fragile-X mental retardation protein (FMRP) is greatly reduced or absent in individuals with fragile-X mental retardation syndrome, a common, heritable form of mental retardation. Morphological studies suggest that this protein functions in normal synapse maturation and neuronal plasticity. Examination of human brain autopsy tissue has shown that fragile-X patients exhibit long, thin spines more frequently, and stubby mushroom-shaped spines less frequently, than these two types of spines are seen in normal autopsy tissue. Fragile-X tissue also has a greater density of these spines along dendrites, which suggests a possible failure of synapse elimination. Fmr1 knockout mice and wild-type litter-mates brains were processed for Timm staining, which reveals the zinc- rich terminals of the dentate gyrus, the mossy fibers. The Fmr1 knockout mice exhibited a pattern of Timm granule-staining within the stratum oriens of subfield CA3 and the inner molecular layer that was significantly different than staining seen in wild-type animals. The sources and consequences of the altered terminal staining are unclear, but are discussed in relation to immature synapse morphology, a failure of normal regression of synapses, and a potential biological penalty of such a failure to regress. (C) 2002 Wiley-Liss, Inc.
引用
收藏
页码:47 / 54
页数:8
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