Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

被引：10

作者：

Katayama, Naoko ^{[1
]}

Orita, Masaya ^{[1
]}

Yamaguchi, Tomohiko ^{[1
]}

Hisamichi, Hiroyuki ^{[1
]}

Kuromitsu, Sadao ^{[1
]}

Kurihara, Hiroyuki ^{[1
]}

Sakashita, Hitoshi ^{[1
]}

Matsumoto, Yuzo ^{[1
]}

Fujita, Shigeo ^{[1
]}

Niimi, Tatsuya ^{[1
]}

机构：

[1] Astellas Pharma Inc, Drug Discovery Res, Tsukuba, Ibaraki 3058585, Japan

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2008年 / 73卷 / 04期

关键词：

binding mode; sequence alignment; Ramachandran; plot; PDB; ERK2; IRK; drug design; hydrogen bond;

D O I：

10.1002/prot.22207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, we report crystal structures for inhibitor-kinase complexes in which the inhibitor has different binding orientations and hydrogen-bonding patterns with extracellular-signal regulated kinase 2 and insulin receptor tyrosine kinase. Our crystallographic studies, and sequence and structural analyses of 532 coordinates of kinases held in the Protein Data Bank, suggest that the length of the "specificity linker" described here is a key structural element of the hydrogen-bonding patterns between protein kinases and their inhibitors.

引用

页码：795 / 801

页数：7

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