Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium

被引:119
作者
Schlecker, Christina
Boehmerle, Wolfgang
Jeromin, Andreas
DeGray, Brenda
Varshney, Anurag
Sharma, Yogendra
Szigeti-Buck, Klara
Ehrlich, Barbara E.
机构
[1] Yale Univ, Dept Pharmacol, New Haven, CT 06520 USA
[2] Univ Magdeburg, Dept Neurosci, D-39106 Magdeburg, Germany
[3] Inst Neurosci, Biol Marine Lab, Woods Hole, MA USA
[4] Charite Univ Med Berlin, Inst Neurophysiol, Berlin, Germany
[5] Univ Texas, Ctr Learning & Memory, Austin, TX 78712 USA
[6] Ctr Cellular & Mol Biol, Hyderabad, Andhra Pradesh, India
关键词
D O I
10.1172/JCI22466
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Regulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP(3)R) has been linked to many cellular processes and pathological conditions. In the present study, addition of neuronal calcium sensor-1 (NCS-1), a high-affinity, low-capacity, calcium-binding protein, to purified InsP(3)R type 1(InsP(3)R1) increased the channel activity in both a calcium-dependent and -independent manner. In intact cells, enhanced expression of NCS-1 resulted in increased intracellular calcium release upon stimulation of the phosphoinositide signaling pathway. To determine whether InsP(3)R1/NCS-1 interaction could be functionally relevant in bipolar disorders, conditions in which NCS-1 is highly expressed, we tested the effect of lithium, a salt widely used for treatment of bipolar disorders. Lithium inhibited the enhancing effect of NCS-1 on InsP(3)R1 function, suggesting that InsP(3)R1/NCS-1 interaction is an essential component of the pathomechanism of bipolar disorder.
引用
收藏
页码:1668 / 1674
页数:7
相关论文
共 40 条
[1]   Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae [J].
Ames, JB ;
Hendricks, KB ;
Strahl, T ;
Huttner, IG ;
Hamasaki, N ;
Thorner, J .
BIOCHEMISTRY, 2000, 39 (40) :12149-12161
[2]   IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis [J].
Bahi, N ;
Friocourt, G ;
Carrié, A ;
Graham, ME ;
Weiss, JL ;
Chafey, P ;
Fauchereau, F ;
Burgoyne, RD ;
Chelly, J .
HUMAN MOLECULAR GENETICS, 2003, 12 (12) :1415-1425
[3]   Calcium signalling: Dynamics, homeostasis and remodelling [J].
Berridge, MJ ;
Bootman, MD ;
Roderick, HL .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (07) :517-529
[4]   LITHIUM AMPLIFIES AGONIST-DEPENDENT PHOSPHATIDYLINOSITOL RESPONSES IN BRAIN AND SALIVARY-GLANDS [J].
BERRIDGE, MJ ;
DOWNES, CP ;
HANLEY, MR .
BIOCHEMICAL JOURNAL, 1982, 206 (03) :587-595
[5]   Neuronal calcium signaling [J].
Berridge, MJ .
NEURON, 1998, 21 (01) :13-26
[6]   Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function [J].
Braunewell, KH ;
Gundelfinger, ED .
CELL AND TISSUE RESEARCH, 1999, 295 (01) :1-12
[7]  
Burgoyne RD, 2001, BIOCHEM J, V353, P1
[8]   Human neuronal calcium sensor-1 shows the highest expression level in cerebral cortex [J].
Chen, CY ;
Yu, L ;
Zhang, PZ ;
Jiang, JM ;
Zhang, YZ ;
Chen, XS ;
Wu, Q ;
Wu, QH ;
Zhao, SY .
NEUROSCIENCE LETTERS, 2002, 319 (02) :67-70
[9]  
Ciccolini F, 2003, J NEUROSCI, V23, P103
[10]  
COX JA, 1994, J BIOL CHEM, V269, P32807