Enantioselective syntheses of (+)-decursinol and (+)-trans-decursidinol

被引：26

作者：

Kim, S

Ko, H

Son, S

Shin, KJ

Kim, DJ

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

[2] Korea Inst Sci & Technol, Seoul 130650, South Korea

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 43期

关键词：

decursinol; decursidinol; Jacobsen's epoxidation; biomimetic synthesis;

D O I：

10.1016/S0040-4039(01)01652-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective and practical asymmetric syntheses of (+)-decursinol (1) and (+)-trans-decursidinol (2) have been achieved using naturally occurring umbelliferone, demethylsuberosin, and xanthyletin as the synthetic intermediates. The absolute stereochemistry was established in the late stage of synthesis by employing Jacobsen's enantioselective epoxidation conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7641 / 7643

页数：3

共 13 条

[1] Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas [J].