On the synthesis of (S)-alpha-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate.

被引：18

作者：

Cativiela, C

DiazdeVillegas, MD

Galvez, JA

Lapena, Y

机构：

[1] Inst. De Cie. De Mat. De Aragon, Depto. De Quim. Orgánica, Universidad De Zaragoza-C.S.I.C

来源：

TETRAHEDRON | 1997年 / 53卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(97)00249-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient procedure for the synthesis of optically pure alpha-methylaspartic acid, based on the diastereoselective alkylation of (1S,2R,4R)-10-(dicyclohexylsulfamoyl)iso 2-cyanopropanoate with alpha-halocarbonyl compounds, is described. (C) 1997 Elsevier Science Ltd.

引用

页码：5891 / 5898

页数：8

共 38 条

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