Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease

被引:72
作者
Atkinson, M. A. [1 ]
Chervonsky, A. [2 ]
机构
[1] Univ Florida, Dept Pathol, Coll Med, Gainesville, FL 32610 USA
[2] Univ Chicago, Dept Pathol, Coll Med, Chicago, IL 60637 USA
基金
美国国家卫生研究院;
关键词
Bacteria; Environment; Gut microbiome; Immunology; Innate immunity; Microbiota; Mucosal immunity; NOD mice; Review; Type; 1; diabetes; INCREASED INTESTINAL PERMEABILITY; SEGMENTED FILAMENTOUS BACTERIA; CESAREAN-SECTION; RISING INCIDENCE; INNATE IMMUNITY; BODY HABITATS; GLUTEN-FREE; NOD MICE; T-CELLS; ONSET;
D O I
10.1007/s00125-012-2672-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite years of appreciating the potential role of environment to influence the pathogenesis of type 1 diabetes, specific agents or mechanisms serving in such a capacity remain ill defined. This is exceedingly disappointing as the identification of factors capable of modulating the disease, either as triggers or regulators of the autoimmune response underlying type 1 diabetes, would not only provide clues as to why the disorder develops but, in addition, afford opportunities for improved biomarkers of disease activity and the potential to design novel therapeutics capable of disease abatement. Recent improvements in sequencing technologies, combined with increasing appreciation of the role of innate and mucosal immunity in human disease, have stirred strong interest in what is commonly referred to as the 'gut microbiota'. The gut (or intestinal) microbiota is an exceedingly complex microenvironment that is intimately linked with the immune system, including the regulation of immune responses. After evaluating evidence supporting a role for environment in type 1 diabetes, this review will convey current notions for contributions of the gut microbiota to human health and disease, including information gleaned from studies of humans and animal models for this autoimmune disorder.
引用
收藏
页码:2868 / 2877
页数:10
相关论文
共 87 条
[51]   PREVENTION OF INSULITIS AND DIABETES ONSET BY TREATMENT WITH COMPLETE FREUND ADJUVANT IN NOD MICE [J].
MCINERNEY, MF ;
PEK, SB ;
THOMAS, DW .
DIABETES, 1991, 40 (06) :715-725
[52]   Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat [J].
Meddings, JB ;
Jarand, J ;
Urbanski, SJ ;
Hardin, J ;
Gall, DG .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1999, 276 (04) :G951-G957
[53]   Characterization of Bacteria in Biopsies of Colon and Stools by High Throughput Sequencing of the V2 Region of Bacterial 16S rRNA Gene in Human [J].
Momozawa, Yukihide ;
Deffontaine, Valerie ;
Louis, Edouard ;
Medrano, Juan F. .
PLOS ONE, 2011, 6 (02)
[54]  
Moore T. A., 2011, ICAN: Infant, Child & Adolescent Nutrition, V3, P291, DOI 10.1177/1941406411421629
[55]   Changes in intestinal morphology and permeability in the BioBreeding rat before the onset of type 1 diabetes [J].
Neu, J ;
Reverte, CM ;
Mackey, AD ;
Liboni, K ;
Tuhacek-Tenace, LM ;
Hatch, M ;
Li, N ;
Caicedo, RA ;
Schatz, DA ;
Atkinson, M .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (05) :589-595
[56]  
Pasteur L., 1885, CR HEBD ACAD SCI, V100, P68
[57]   A human gut microbial gene catalogue established by metagenomic sequencing [J].
Qin, Junjie ;
Li, Ruiqiang ;
Raes, Jeroen ;
Arumugam, Manimozhiyan ;
Burgdorf, Kristoffer Solvsten ;
Manichanh, Chaysavanh ;
Nielsen, Trine ;
Pons, Nicolas ;
Levenez, Florence ;
Yamada, Takuji ;
Mende, Daniel R. ;
Li, Junhua ;
Xu, Junming ;
Li, Shaochuan ;
Li, Dongfang ;
Cao, Jianjun ;
Wang, Bo ;
Liang, Huiqing ;
Zheng, Huisong ;
Xie, Yinlong ;
Tap, Julien ;
Lepage, Patricia ;
Bertalan, Marcelo ;
Batto, Jean-Michel ;
Hansen, Torben ;
Le Paslier, Denis ;
Linneberg, Allan ;
Nielsen, H. Bjorn ;
Pelletier, Eric ;
Renault, Pierre ;
Sicheritz-Ponten, Thomas ;
Turner, Keith ;
Zhu, Hongmei ;
Yu, Chang ;
Li, Shengting ;
Jian, Min ;
Zhou, Yan ;
Li, Yingrui ;
Zhang, Xiuqing ;
Li, Songgang ;
Qin, Nan ;
Yang, Huanming ;
Wang, Jian ;
Brunak, Soren ;
Dore, Joel ;
Guarner, Francisco ;
Kristiansen, Karsten ;
Pedersen, Oluf ;
Parkhill, Julian ;
Weissenbach, Jean .
NATURE, 2010, 464 (7285) :59-U70
[58]   CULTIVATION OF BACTERIA-FREE HYDRA-VIRIDIS - MISSING BUDDING FACTOR IN NON-SYMBIOTIC HYDRA [J].
RAHAT, M ;
DIMENTMAN, C .
SCIENCE, 1982, 216 (4541) :67-68
[59]   Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis [J].
Rakoff-Nahoum, S ;
Paglino, J ;
Eslami-Varzaneh, F ;
Edberg, S ;
Medzhitov, R .
CELL, 2004, 118 (02) :229-241
[60]   Immunotherapy for the Prevention and Treatment of Type 1 Diabetes Human trials and a look into the future [J].
Rewers, Marian ;
Gottlieb, Peter .
DIABETES CARE, 2009, 32 (10) :1769-1782