Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

被引：49

作者：

Batchelor, AM ^{[1
]}

Knopfel, T ^{[1
]}

Gasparini, F ^{[1
]}

Garthwaite, J ^{[1
]}

机构：

[1] CIBA GEIGY AG, CH-4002 BASEL, SWITZERLAND

来源：

NEUROPHARMACOLOGY | 1997年 / 36卷 / 03期

基金：

英国惠康基金;

关键词：

glutamate; metabotropic glutamate receptor; cerebellum; mGlu1; receptor; synaptic transmission; EPSP;

D O I：

10.1016/S0028-3908(97)00014-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blacked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：401 / 403

页数：3

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