Exacerbation of psoriatic skin lesions in a patient with Alzheimer disease receiving gamma-secretase inhibitor

被引：15

作者：

Hsu, Chao-Kai ^{[1
,2
]}

Hsu, Chia-Chi ^{[1
]}

Lee, Julia Yu-Yun ^{[1
]}

Kuo, Yu-Min ^{[3
]}

Pai, Ming-Chyi ^{[4
,5
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Dermatol, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Coll Med & Hosp, Inst Clin Med, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Cell Biol & Anat, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Neurol, Div Behav Neurol, Tainan, Taiwan

[5] Natl Cheng Kung Univ, Coll Med & Hosp, Alzheimers Dis Res Ctr, Tainan, Taiwan

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2013年 / 68卷 / 02期

关键词：

D O I：

10.1016/j.jaad.2012.07.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

[No abstract available]

引用

页码：E46 / E48

页数：4

共 6 条

[1]

Role of the APP non-amyloidogenic signaling pathway and targeting α-secretase as an alternative drug target for treatment of Alzheimer's disease [J].

Bandyopadhyay, S. ;

Goldstein, L. E. ;

Lahiri, D. K. ;

Rogers, J. T. .

CURRENT MEDICINAL CHEMISTRY, 2007, 14 (27) :2848-2864

[2]

A γ-Secretase Inhibitor Decreases Amyloid-β Production in the Central Nervous System [J].

Bateman, Randall J. ;

Siemers, Eric R. ;

Mawuenyega, Kwasi G. ;

Wen, Guolin ;

Browning, Karen R. ;

Sigurdson, Wendy C. ;

Yarasheski, Kevin E. ;

Friedrich, Stuart W. ;

DeMattos, Ronald B. ;

May, Patrick C. ;

Paul, Steven M. ;

Holtzman, David M. .

ANNALS OF NEUROLOGY, 2009, 66 (01) :48-54

[3]

Alzheimer's failure raises questions about disease-modifying strategies [J].

Extance, Andy .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (10) :749-U87

[4]

Phase 2 safety trial targeting amyloid β production with a γ-secretase inhibitor in Alzheimer disease [J].

Fleisher, Adam S. ;

Raman, Rema ;

Siemers, Eric R. ;

Becerra, Lida ;

Clark, Christopher M. ;

Dean, Robert A. ;

Farlow, Martin R. ;

Galvin, James E. ;

Peskind, Elaine R. ;

Quinn, Joseph F. ;

Sherzai, Abdullah ;

Sowell, Brooke ;

Aisen, Paul S. ;

Thal, Leon J. .

ARCHIVES OF NEUROLOGY, 2008, 65 (08) :1031-1038

[5]

Notch signaling: Its role in epidermal homeostasis and in the pathogenesis of skin diseases [J].

Okuyama, Ryuhei ;

Tagami, Hachiro ;

Aiba, Setsuya .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2008, 49 (03) :187-194

[6]

Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPα-release [J].

Siemes, C ;

Quast, T ;

Klein, E ;

Bieber, T ;

Hooper, NM ;

Herzog, V .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (03) :556-563

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