Immortalisation and transformation revisited

被引：102

作者：

Drayton, S ^{[1
]}

Peters, G ^{[1
]}

机构：

[1] Imperial Canc Res Fund, London WC2A 3PX, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(01)00271-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Access to cDNA encoding the catalytic subunit of telomerase and the consequent ability to immortalise human cells in culture has enabled researchers to 'transform' normal cells into malignant clones. However, there is a continuing debate over the number of genetic alterations required and clear differences in the way that mouse and human cells respond to these alterations.

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页码：98 / 104

页数：7

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