A unified architecture of transcriptional regulatory elements

被引：138

作者：

Andersson, Robin ^{[1
]}

Sandelin, Albin ^{[1
,2
]}

Danko, Charles G. ^{[3
,4
]}

机构：

[1] Univ Copenhagen, Bioinformat Ctr, Dept Biol, Copenhagen, Denmark

[2] Univ Copenhagen, BRIC, Copenhagen, Denmark

[3] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, Ithaca, NY 14853 USA

[4] Cornell Univ, Coll Vet Med, Dept Biomed Sci, Ithaca, NY 14853 USA

来源：

TRENDS IN GENETICS | 2015年 / 31卷 / 08期

基金：

欧洲研究理事会;

关键词：

transcriptional regulation; enhancer; promoter; core promoter; eRNA; RANGE CHROMOSOMAL INTERACTIONS; U1; SNRNP; HISTONE MODIFICATIONS; CHROMATIN SIGNATURES; TRI-METHYLATION; GLOBIN GENE; BETA-GLOBIN; ENHANCERS; PROMOTER; DISTINCT;

D O I：

10.1016/j.tig.2015.05.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.

引用

页码：426 / 433

页数：8

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