Addressing insulin resistance in Type 1 diabetes

被引：59

作者：

Pang, T. T. L. ^{[1
]}

Narendran, P. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Div Med Sci, Birmingham, W Midlands, England

来源：

DIABETIC MEDICINE | 2008年 / 25卷 / 09期

关键词：

complicationis; insulin resistance; meta-analysis; metformin; Type I diabetes;

D O I：

10.1111/j.1464-5491.2008.02493.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes is recognised to include an element of insulin resistance. Insulin resistance is an independent risk factor for the development of macro- and microvascular complications of Type 1 diabetes and may also contribute to the development of the disease. This understanding comes at a time when the incidence of Type 1 diabetes appears to be rising and the public health burden from its vascular complications is high. A variety of safe and efficacious manoeuvres are available to redress insulin resistance in Type 2 diabetes. So far however, clinical trials addressing insulin resistance in Type 1 diabetes have been small with only short periods of follow-up. Regardless, these trials have yielded promising results. This review examines the evidence for insulin resistance in the pathophysiology of Type I diabetes and its complications, the problems associated with its measurement, and summarizes the trials aimed at reducing insulin resistance in Type I diabetes. This includes a meta-analysis of controlled trials of adjuvant metformin in Type I diabetes.

引用

页码：1015 / 1024

页数：10

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