Population genomics of post-vaccine changes in pneumococcal epidemiology

被引：275

作者：

Croucher, Nicholas J. ^{[1
,2
]}

Finkelstein, Jonathan A. ^{[3
,4
,5
]}

Pelton, Stephen I. ^{[6
]}

Mitchell, Patrick K. ^{[1
]}

Lee, Grace M. ^{[3
,4
,7
,8
]}

Parkhill, Julian ^{[2
]}

Bentley, Stephen D. ^{[2
,9
]}

Hanage, William P. ^{[1
]}

Lipsitch, Marc ^{[1
,10
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Ctr Communicable Dis Dynam, Boston, MA 02115 USA

[2] Wellcome Trust Sanger Inst, Cambridge, England

[3] Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA

[4] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[5] Boston Childrens Hosp, Div Gen Pediat, Boston, MA USA

[6] Boston Univ, Med Ctr, Maxwell Finland Lab Infect Dis, Boston, MA USA

[7] Boston Childrens Hosp, Dept Lab Med, Boston, MA USA

[8] Boston Childrens Hosp, Dept Med, Div Infect Dis, Boston, MA USA

[9] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England

[10] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2013年 / 45卷 / 06期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

RESISTANT STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; UNITED-STATES; SEROTYPE; 19A; MASSACHUSETTS; DISEASE; EVOLUTION; ERA; CARRIAGE; CHILDREN;

D O I：

10.1038/ng.2625

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

Whole-genome sequencing of 616 asymptomatically carried Streptococcus pneumoniae isolates was used to study the impact of the 7-valent pneumococcal conjugate vaccine. Comparison of closely related isolates showed the role of transformation in facilitating capsule switching to non-vaccine serotypes and the emergence of drug resistance. However, such recombination was found to occur at significantly different rates across the species, and the evolution of the population was primarily driven by changes in the frequency of distinct genotypes extant before the introduction of the vaccine. These alterations resulted in little overall effect on accessory genome composition at the population level, contrasting with the decrease in pneumococcal disease rates after the vaccine's introduction.

引用

页码：656 / +

页数：10

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