Coordinated Chemomechanical Cycles: A Mechanism for Autonomous Molecular Motion

被引：153

作者：

Green, S. J. ^{[1
]}

Bath, J. ^{[1
]}

Turberfield, A. J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Phys, Oxford OX1 3PU, England

来源：

PHYSICAL REVIEW LETTERS | 2008年 / 101卷 / 23期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1103/PhysRevLett.101.238101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The second law of thermodynamics requires that directed motion be accompanied by dissipation of energy. Here we demonstrate the working principles of a bipedal molecular motor. The motor is constructed from DNA and is driven by the hybridization of a DNA fuel. We show how the catalytic activities of the feet can be coordinated to create a Brownian ratchet that is in principle capable of directional and processive movement along a track. This system can be driven away from equilibrium, demonstrating the potential of the motor to do work.

引用

页数：4

共 28 条

[1] A free-running DNA motor powered by a nicking enzyme [J].