Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test

被引：69

作者：

Almeida, Valeria ^{[1
,2
]}

Levin, Raquel ^{[1
,2
]}

Peres, Fernanda Fiel ^{[1
,2
]}

Niigaki, Suzy T. ^{[1
,2
]}

Calzavara, Mariana B. ^{[2
]}

Zuardi, Antonio W. ^{[3
,4
]}

Hallak, Jaime E. ^{[3
,4
]}

Crippa, Jose A. ^{[3
,4
]}

Abilio, Vanessa C. ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo, Dept Farmacol, UNIFESP, Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, UNIFESP, Lab Interdisciplinar Neurociencias Clin, Sao Paulo, Brazil

[3] Univ Sao Paulo, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, Brazil

[4] Inst Nacl Ciencia & Tecnol Translac Med, INCT TM, CNPq, Ribeirao Preto, Brazil

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2013年 / 41卷

基金：

巴西圣保罗研究基金会;

关键词：

Anxiety; Cannabidiol; Schizophrenia; SHR; Social interaction test; SPONTANEOUSLY HYPERTENSIVE-RATS; ELEVATED PLUS-MAZE; WISTAR-KYOTO WKY; OPEN-FIELD; ANIMAL-MODELS; ENDOCANNABINOID SYSTEM; STEREOTYPED BEHAVIOR; D-AMPHETAMINE; SCHIZOPHRENIA; ANXIETY;

D O I：

10.1016/j.pnpbp.2012.10.024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recently reported that Spontaneously Hypertensive Rats (SHRs) present a deficit in social interaction that is ameliorated by atypical antipsychotics. In addition, SHRs present a hyperlocomotion that is reverted by typical and atypical antipsychotics, suggesting that this strain could be useful to study negative symptoms (modeled by a decrease in social interaction) and positive symptoms (modeled by hyperlocomotion) of schizophrenia as well as the effects of potential antipsychotics drugs. At the same time, an increase in social interaction in control animals similar to that induced by benzodiazepines is used to screen potential anxiolytic drugs. The aim of this study was to investigate the effects of CBD on social interaction presented by control animals (Wistar) and SHRs. The lowest dose of CBD (1 mg/kg) increased passive and total social interaction of Wistar rats. However, the hyperlocomotion and the deficit in social interaction displayed by SHRs were not altered by any dose of CBD. Our results do not support an antipsychotic property of cannabidiol on symptoms-like behaviors in SHRs but reinforce the anxiolytic profile of this compound in control rats. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：30 / 35

页数：6

共 76 条

[11] Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report [J].

Crippa, Jose Alexandre S. ;

Derenusson, Guilherme Nogueira ;

Ferrari, Thiago Borduqui ;

Wichert-Ana, Lauro ;

Duran, Fabio L. S. ;

Martin-Santos, Rocio ;

Simoes, Marcus Vinicius ;

Bhattacharyya, Sagnik ;

Fusar-Poli, Paolo ;

Atakan, Zerrin ;

Filho, Alaor Santos ;

Freitas-Ferrari, Maria Cecilia ;

McGuire, Philip K. ;

Zuardi, Antonio Waldo ;

Busatto, Geraldo F. ;

Cecilio Hallak, Jaime Eduardo .

JOURNAL OF PSYCHOPHARMACOLOGY, 2011, 25 (01) :121-130

[12]

Crippa JAS, 2010, REV BRAS PSIQUIATR, V32, pS56

[13] CHRONIC ADMINISTRATION OF CANNABIDIOL TO HEALTHY-VOLUNTEERS AND EPILEPTIC PATIENTS [J].

CUNHA, JM ;

CARLINI, EA ;

PEREIRA, AE ;

RAMOS, OL ;

PIMENTEL, C ;

GAGLIARDI, R ;

SANVITO, WL ;

LANDER, N ;

MECHOULAM, R .

PHARMACOLOGY, 1980, 21 (03) :175-185

[14] Does hypertension alone lead to cognitive decline in spontaneously hypertensive rats? [J].

Diana, G .

BEHAVIOURAL BRAIN RESEARCH, 2002, 134 (1-2) :113-121

[15] Comparisons of behavioral and neurochemical characteristics between WKY, WKHA, and Wistar rat strains [J].

Drolet, G ;

Proulx, K ;

Pearson, D ;

Rochford, J ;

Deschepper, CF .

NEUROPSYCHOPHARMACOLOGY, 2002, 27 (03) :400-409

[16] Sleep in the Wistar-Kyoto rat, a putative genetic animal model for depression [J].

Dugovic, C ;

Solberg, LC ;

Redei, E ;

Van Reeth, G ;

Turek, FW .

NEUROREPORT, 2000, 11 (03) :627-631

[17] A review of 25 years of the social interaction test [J].

File, SE ;

Seth, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 463 (1-3) :35-53

[18] CAN SOCIAL-INTERACTION BE USED TO MEASURE ANXIETY [J].

FILE, SE ;

HYDE, JRG .

BRITISH JOURNAL OF PHARMACOLOGY, 1978, 62 (01) :19-24

[19] OPEN-FIELD AND ELEVATED PLUS-MAZE - A BEHAVIORAL-COMPARISON BETWEEN SPONTANEOUSLY HYPERTENSIVE (SHR) AND WISTAR-KYOTO (WKY) RATS AND THE EFFECTS OF CHLORDIAZEPOXIDE [J].

GENTSCH, C ;

LICHTSTEINER, M ;

FEER, H .

BEHAVIOURAL BRAIN RESEARCH, 1987, 25 (02) :101-107

[20] ANTIANXIETY EFFECT OF CANNABIDIOL IN THE ELEVATED PLUS-MAZE [J].

GUIMARAES, FS ;

CHIARETTI, TM ;

GRAEFF, FG ;

ZUARDI, AW .

PSYCHOPHARMACOLOGY, 1990, 100 (04) :558-559

← 1 2 3 4 5 6 7 8 →