A practical synthesis of essentially enantiopure syn-propionate aldols using a chiral oxazaborolidinone-promoted asymmetric aldol reaction coupled with radical reduction

被引：32

作者：

Kiyooka, S ^{[1
]}

Shahid, KA ^{[1
]}

Hena, MA ^{[1
]}

机构：

[1] Kochi Univ, Dept Chem, Akebono Cho, Kochi 7808520, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 35期

关键词：

asymmetric aldol reaction; chiral Lewis acid; diastereoselective radical reduction;

D O I：

10.1016/S0040-4039(99)01278-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Essentially enantiopure syn-propionate aldols (>98% ee) were prepared by a chiral oxazaborolidinone-promoted asymmetric aldol reaction, followed by a diastereoselective radical reduction with Bu3SnH and Et3B, which was carried out under chelation control. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：6447 / 6449

页数：3

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