Enantioselective acyclic stereoselection under catalyst control .3. A very short asymmetric synthesis of the bryostatin C-1-C-9 segment using the chiral oxazaborolidinone-promoted aldol reaction

被引：42

作者：

Kiyooka, S

Maeda, H

机构：

[1] Department of Chemistry, Kochi University, Kochi 780, Akebono-cho

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(97)00461-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A very short asymmetric synthesis of the bryostatin C-1-C-9 segment was achieved by three sequential chiral oxazaborolidinone-promoted aldol reactions under 'catalyst control'. This synthetic methodology is based on a direct asymmetric incorporation of two acetate and one isobutyrate synthones into the framework. (C) 1997 Elsevier Science Ltd.

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页码：3371 / 3374

页数：4

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