Asymmetric synthesis of the C(10)-C(16) segment of the bryostatins

被引：46

作者：

Lampe, TFJ ^{[1
]}

Hoffmann, HMR ^{[1
]}

机构：

[1] UNIV HANNOVER,DEPT ORGAN CHEM,D-30167 HANNOVER,GERMANY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 43期

关键词：

D O I：

10.1016/0040-4039(96)01759-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C(10)-C(16) segment of the bryostatins has been synthesized (12 steps, 15% overall yield) and a cyanohydrin based strategy was developed for coupling with a C(I)-C(9) model. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7695 / 7698

页数：4

共 12 条

[1] CONTROL OF REMOTE ENOATE GEOMETRY IN THE BRYOSTATINS WITH A TETHERED HORNER-WADSWORTH-EMMONS REAGENT [J].

EVANS, DA ;

CARREIRA, EM .

TETRAHEDRON LETTERS, 1990, 31 (33) :4703-4706

[2] DIASTEREOSELECTIVE BROMINE/LITHIUM-EXCHANGE APPLIED TO THE SYNTHESIS OF A C-1/C-9-SEGMENT OF BRYOSTATINS [J].

HOFFMANN, RW ;

STIASNY, HC .

TETRAHEDRON LETTERS, 1995, 36 (26) :4595-4598

[3] SYNTHESIS OF BRYOSTATIN-7 [J].

KAGEYAMA, M ;

TAMURA, T ;

NANTZ, MH ;

ROBERTS, JC ;

SOMFAI, P ;

WHRITENOUR, DC ;

MASAMUNE, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (20) :7407-7408

[4] Enantioselective synthesis of the C1-C9 segment of bryostatin by kinetic resolution of racemic alpha-keto esters [J].

Kalesse, M ;

Eh, M .

TETRAHEDRON LETTERS, 1996, 37 (11) :1767-1770

[5] THE TRIPHENYLMETHYL (TRITYL) GROUP AND ITS USES IN NUCLEOTIDE CHEMISTRY [J].

KOHLI, V ;

BLOCKER, H ;

KOSTER, H .

TETRAHEDRON LETTERS, 1980, 21 (28) :2683-2686

[6]

LAMPE TFJ, UNPUB CHEM COMM

[7]

LAMPE TFJ, 1996, J CHEM SOC CHEM COMM, P1931

[8]

LAMPE TFJ, 1996, IN PRESS TETRAHEDRON, V7

[9] TOTAL SYNTHESIS OF BIOACTIVE MARINE MACROLIDES [J].

NORCROSS, RD ;

PATERSON, I .

CHEMICAL REVIEWS, 1995, 95 (06) :2041-2114

[10]

Pettit G. R., 1989, CHEMIST, P11

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