Highly antimalaria-active artemisinin derivatives: Biological activity does not correlate with chemical reactivity

被引：113

作者：

Haynes, RK ^{[1
]}

Ho, WY

Chan, HW

Fugmann, B

Stetter, J

Croft, SL

Vivas, L

Peters, W

Robinson, BL

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

[2] Bayer AG, Cent Res, Med Chem, D-51368 Leverkusen, Germany

[3] Bayer AG, Cent Res, Chem Life Sci, D-51368 Leverkusen, Germany

[4] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[5] Northwick Pk Inst Med Res, Ctr Trop Antiprotozoal Chemotherapy, Harrow HA1 3UJ, Middx, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 11期

关键词：

heme proteins; iron; medicinal chemistry; peroxides; radicals;

D O I：

10.1002/anie.200352343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New leads for antimalarial drugs? 10-Alkylaminoartemisinin derivatives like that shown display in vivo antimalarial activities greater than those of the parent artemisinin. Previous conclusions regarding the chemical basis for the antimalarial activity of these compounds must be reconsidered.

引用

页码：1381 / 1385

页数：5

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