Transition metal catalyzed neoglycoconjugate syntheses

被引：56

作者：

Roy, R ^{[1
]}

Das, SK ^{[1
]}

Dominique, R ^{[1
]}

Trono, MC ^{[1
]}

Hernández-Mateo, F ^{[1
]}

Santoyo-González, F ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ottawa, ON K1N 6N5, Canada

来源：

PURE AND APPLIED CHEMISTRY | 1999年 / 71卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1351/pac199971040565

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbohydrate-containing clusters of various valency were synthesized using transition metal-catalyzed reactions. Thus, Grubbs' ruthenium benzylidene catalyst was used successfully in olefin self-and cross-metathesis reactions from both O-and C-alkenyl glycopyranosides. The reaction was also used to generate C-linked pseudodisaccharides. Oxidative dimerization of terminal alkynes such as 2-propynyl glycopyranosides was accomplished with coupling between 2-propynyl and 4-iodophenyl mannopyranosides afforded novel sugar-rods useful in studying carbohydrate-protein interactions. Cyclotrimerization of terminal as well as symmetrical alkyne derivatives with dicobalt octacarbonyl allowed access to trimers and hexamers, respectively.

引用

页码：565 / 571

页数：7

共 47 条

[41] Catalytic applications of transition metals in organic synthesis [J].