A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides

被引:33
作者
Rijkers, DTS [1 ]
van Vugt, HHR [1 ]
Jacobs, HJF [1 ]
Liskamp, RMJ [1 ]
机构
[1] Univ Utrecht, Fac Pharmaceut Sci, Utrecht Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands
关键词
azides; azido peptides; diazo transfers; solid phase synthesis;
D O I
10.1016/S0040-4039(02)00629-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient method for the conversion of solid phase bound peptide amines into azides by a diazo transfer using triflyl azide in the presence of divalent copper ions is described. alpha-Azido acids and azido peptides-up to 30 amino acids in length-are obtained in good yields and high purities after cleavage from the solid support. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
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页码:3657 / 3660
页数:4
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