Relationship of energy metabolism detected by 31P-MRS in the human brain with mental fatigue

被引:18
作者
Kato, T
Murashita, J
Shioiri, T
Inubushi, T
Kato, N
机构
[1] Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan
[2] Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 52021, Japan
[3] Shiga Univ Med Sci, Mol Neurobiol Res Ctr, Otsu, Shiga 52021, Japan
关键词
phosphorus-31 magnetic resonance spectroscopy; creatine phosphate; intracellular pH; functional brain activation study; serial calculation task; occipital robe; Uchida-Kraepelin test;
D O I
10.1159/000026587
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To search for a possible relationship between brain energy metabolism and mental fatiguability, 10 normal volunteers were examined by P-31-MRS (phosphorus-31 magnetic resonance spectroscopy) in the occipital cortex during photic stimulation (PS), and Uchida-Kraepelin test (UKT), a standardized serial calculation task, was used for measurement of intraindividual characteristics of mental fatigue in these subjects. More decrease of phosphocreatine measured by P-31-MRS during the PS was significantly associated with more effects of rest assessed by UKT (r = -0.86, p <0.005), More decrease in pH after PS was associated with steeper decline of performance (r = 0.78, p <0.01). These findings suggest that characteristics of brain energy metabolism in an individual may relate to intrinsic patterns of mental fatigability.
引用
收藏
页码:214 / 218
页数:5
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