L-prolinamide-catalyzed direct nitroso aldol reactions of α-branched aldehydes:: a distinct regioselectivity from that with L-proline

被引：89

作者：

Guo, HM

Cheng, L

Cun, LF

Gong, LZ ^{[1
]}

Mi, AQ

Jiang, YZ

机构：

[1] Chinese Acad Sci, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Union Lab Asymmetr Synth, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[3] Henan Normal Univ, Dept Chem, Xinxiang 453002, Henan, Peoples R China

[4] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 04期

关键词：

D O I：

10.1039/b514194j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first direct enantioselective N-nitroso aldol reaction of aldehyde with nitrosobenzene catalyzed by an L-prolinamide derivative is presented; the reactions proceed smoothly furnishing the a-hydroxyamino carbonyl compounds, the otherwise disfavored products, in good yields with up to 64% ee.

引用

收藏

页码：429 / 431

页数：3

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