Cardiovascular risk in subjects with high probability of metabolic syndrome and insulin resistance: DESIRE study.

被引:10
作者
Goday, A. [1 ]
Gabriel, R. [2 ]
Ascaso, J. F. [3 ,4 ]
Franch, J.
Ortega, R.
Martinez, O.
Lerones, N.
机构
[1] Univ Autonoma Barcelona, Hosp Mar, Serv Endocrinol, Barcelona 08003, Spain
[2] Hosp La Paz, Red RECAVA, Unidad Invest, Madrid, Spain
[3] Univ Valencia, Hosp Clin Univ Valencia, Serv Endocrinol, E-46003 Valencia, Spain
[4] Ctr Raval, Atenc Primaria, Barcelona, Spain
来源
REVISTA CLINICA ESPANOLA | 2008年 / 208卷 / 08期
关键词
metabolic syndrome; insulin resistance; cardiovascular risk;
D O I
10.1157/13126339
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Introduction and objectives. The metabolic syndrome is an association of closely related alterations. The main objective of this study is to know the frequency of the metabolic syndrome and insulin resistance, and their role as cardiovascular risk indicators in an adult population assigned to Primary Care centers in Spain. Methods. Subjects >= 45 years with basal glycemia >= 90 mg/dl and abdominal circumference >= 94 cm (men) or >= 80 cm (women). ATP III modified-criteria were used for the metabolic syndrome and HOMA index > 3.29 was used for insulin resistance. Cardiovascular risk was estimated by the Framingham and SCORE models. Results. A total of 2,341 subjects (62 +/- 10 years; 44.6% males) were included. Frequency of metabolic syndrome and insulin resistance was 54.6% (52.5; 56.8) and 56.6% (54.5; 58.7) respectively. Metabolic syndrome was associated to a higher cardiovascular risk score with both Framingham (16 [15; 16] vs 11 [11; 12] p < 0.0001) and SCORE (2.7 [2.4; 3] vs 2.4 [2.1; 2.8]; p = 0.006) models. The results were similar for the presence of insulin resistance. Conclusions. Metabolic syndrome and insulin resistance are cardiovascular risk predictors. Early identification of metabolic syndrome by the use of simple clinical measures (basal glycemia and waist circumference) would make the intervention on the different disorders of metabolic syndrome possible.
引用
收藏
页码:377 / 385
页数:9
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