Pulsatile Drug Release from PLGA Hollow Microspheres by Controlling the Permeability of Their Walls with a Magnetic Field

被引：72

作者：

Chiang, Wei-Lun ^{[3
]}

Ke, Cherng-Jyh ^{[3
]}

Liao, Zi-Xian ^{[3
]}

Chen, San-Yuan ^{[4
]}

Chen, Fu-Rong ^{[5
]}

Tsai, Chun-Ying ^{[5
]}

Xia, Younan ^{[1
,2
]}

Sung, Hsing-Wen ^{[3
]}

机构：

[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[2] Emory Univ, Atlanta, GA 30332 USA

[3] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan

[4] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 30013, Taiwan

[5] Natl Tsing Hua Univ, Dept Engn & Syst Sci, Hsinchu 30013, Taiwan

来源：

SMALL | 2012年 / 8卷 / 23期

关键词：

pulsatile drug release; molecular switches; magnetic stimulus; iron oxide nanoparticles; DELIVERY; DESIGN; SYSTEM; NANOPARTICLES;

D O I：

10.1002/smll.201201743

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pulsatile release: When a high-frequency magnetic field is applied, heat will be generated by coupling to the iron oxide nanoparticles encapsulated in the shells of PLGA hollow microspheres. As the temperature approaches the T g of PLGA, the polymer chains become more mobile, subsequently increasing the free volume of PLGA matrix and significantly enhancing the diffusion of drug molecules. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3584 / 3588

页数：5

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