Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?

被引：136

作者：

Berry, David ^{[1
]}

Reinisch, Walter ^{[2
]}

机构：

[1] Univ Vienna, Fac Life Sci, Dept Microbial Ecol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, A-1090 Vienna, Austria

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2013年 / 27卷 / 01期

关键词：

Microbial biomarker; Dysbiosis; Enterobacteriaceae; Lachnospiraceae; Faecalibacterium prausnitzii; MUCOSA-ASSOCIATED MICROBIOTA; INVASIVE ESCHERICHIA-COLI; SULFATE-REDUCING BACTERIA; ACTIVE CROHNS-DISEASE; ULCERATIVE-COLITIS; GUT MICROBIOTA; FECAL MICROBIOTA; GASTROINTESTINAL MICROBIOTA; HIGH PREVALENCE; FAECALIBACTERIUM-PRAUSNITZII;

D O I：

10.1016/j.bpg.2013.03.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The human intestine harbours a complex microbial ecosystem that performs manifold functions important to the nutrition and health of its host. Extensive study has revealed that the composition of the intestinal microbiota is altered in individuals with inflammatory bowel disease (IBD). The IBD associated intestinal microbiota generally has reduced species richness and diversity, lower temporal stability, and disruption of the secreted mucus layer structure. Multiple studies have identified certain bacterial taxa that are enriched or depleted in IBD including Enterobacteriaceae, Ruminococcus gnavus, and Desulfovibrio (enriched) and Faecalibacterium prausnitzii, Lachnospiraceae, and Akkermansia (depleted). Additionally, the relative abundance of some taxa appears to correlate with established markers of disease activity such as Enterobacteriaceae (enriched) and Lachnospiraceae (depleted). Signature shifts in fecal microbial community composition may therefore prove to be valuable as diagnostic biomarkers, particularly for longitudinal monitoring of disease activity and response to treatments. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：47 / 58

页数：12

共 101 条

[31] Development of the Human Gastrointestinal Microbiota and Insights From High-Throughput Sequencing [J].

Dominguez-Bello, Maria Gloria ;

Blaser, Martin J. ;

Ley, Ruth E. ;

Knight, Rob .

GASTROENTEROLOGY, 2011, 140 (06) :1713-1719

[32] Predicting a Human Gut Microbiota's Response to Diet in Gnotobiotic Mice [J].

Faith, Jeremiah J. ;

McNulty, Nathan P. ;

Rey, Federico E. ;

Gordon, Jeffrey I. .

SCIENCE, 2011, 333 (6038) :101-104

[33] Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis [J].

Feller, Martin ;

Huwiler, Karin ;

Stephan, Roger ;

Altpeter, Ekkehardt ;

Shang, Aijing ;

Furrer, Hansjakob ;

Pfyffer, Gaby E. ;

Jemmi, Thomas ;

Baumgartner, Andreas ;

Egger, Matthias .

LANCET INFECTIOUS DISEASES, 2007, 7 (09) :607-613

[34] Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases [J].

Frank, Daniel N. ;

Amand, Allison L. St. ;

Feldman, Robert A. ;

Boedeker, Edgar C. ;

Harpaz, Noam ;

Pace, Norman R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (34) :13780-13785

[35] Disease Phenotype and Genotype Are Associated with Shifts in Intestinal-associated Microbiota in Inflammatory Bowel Diseases [J].

Frank, Daniel N. ;

Robertson, Charles E. ;

Hamm, Christina M. ;

Kpadeh, Zegbeh ;

Zhang, Tianyi ;

Chen, Hongyan ;

Zhu, Wei ;

Sartor, R. Balfour ;

Boedeker, Edgar C. ;

Harpaz, Noam ;

Pace, Norman R. ;

Li, Ellen .

INFLAMMATORY BOWEL DISEASES, 2011, 17 (01) :179-184

[36] Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization [J].

Fuhrer, Andrea ;

Sprenger, Norbert ;

Kurakevich, Ekaterina ;

Borsig, Lubor ;

Chassard, Christophe ;

Hennet, Thierry .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (13) :2843-2854

[37] Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system [J].

Garrett, Wendy S. ;

Lord, Graham M. ;

Punit, Shivesh ;

Lugo-Villarino, Geanncarlo ;

Mazmanian, Sarkis K. ;

Ito, Susumu ;

Glickman, Jonathan N. ;

Glimcher, Laurie H. .

CELL, 2007, 131 (01) :33-45

[38] Inerences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis [J].

Gophna, Uri ;

Sommerfeld, Katrin ;

Gophna, Sharon ;

Doolittle, W. Ford ;

van Zanten, Sander J. O. Veldhuyzen .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (11) :4136-4141

[39] Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis [J].

Hansen, Richard ;

Russell, Richard K. ;

Reiff, Caroline ;

Louis, Petra ;

McIntosh, Freda ;

Berry, Susan H. ;

Mukhopadhya, Indrani ;

Bisset, W. Michael ;

Barclay, Andy R. ;

Bishop, Jon ;

Flynn, Diana M. ;

McGrogan, Paraic ;

Loganathan, Sabarinathan ;

Mahdi, Gamal ;

Flint, Harry J. ;

El-Omar, Emad M. ;

Hold, Georgina L. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2012, 107 (12) :1913-1922

[40] Structure, function and diversity of the healthy human microbiome [J].

Huttenhower, Curtis ;

Gevers, Dirk ;

Knight, Rob ;

Abubucker, Sahar ;

Badger, Jonathan H. ;

Chinwalla, Asif T. ;

Creasy, Heather H. ;

Earl, Ashlee M. ;

FitzGerald, Michael G. ;

Fulton, Robert S. ;

Giglio, Michelle G. ;

Hallsworth-Pepin, Kymberlie ;

Lobos, Elizabeth A. ;

Madupu, Ramana ;

Magrini, Vincent ;

Martin, John C. ;

Mitreva, Makedonka ;

Muzny, Donna M. ;

Sodergren, Erica J. ;

Versalovic, James ;

Wollam, Aye M. ;

Worley, Kim C. ;

Wortman, Jennifer R. ;

Young, Sarah K. ;

Zeng, Qiandong ;

Aagaard, Kjersti M. ;

Abolude, Olukemi O. ;

Allen-Vercoe, Emma ;

Alm, Eric J. ;

Alvarado, Lucia ;

Andersen, Gary L. ;

Anderson, Scott ;

Appelbaum, Elizabeth ;

Arachchi, Harindra M. ;

Armitage, Gary ;

Arze, Cesar A. ;

Ayvaz, Tulin ;

Baker, Carl C. ;

Begg, Lisa ;

Belachew, Tsegahiwot ;

Bhonagiri, Veena ;

Bihan, Monika ;

Blaser, Martin J. ;

Bloom, Toby ;

Bonazzi, Vivien ;

Brooks, J. Paul ;

Buck, Gregory A. ;

Buhay, Christian J. ;

Busam, Dana A. ;

Campbell, Joseph L. .

NATURE, 2012, 486 (7402) :207-214

← 1 2 3 4 5 6 7 8 9 10 →