Mediated biosensors

Direct electrode transfer between enzyme and the electrode in biosensors requires high efficiency therefore, synthetic replacement for oxygen led to the development of enzyme mediators and modified electrodes in biosensor fabrication. In this context, a number of electron acceptors and complexes have been used. Present paper gives an overview of various methodologies involved in the mediated systems, their merits and wide applications. (C) 2002 Elsevier Science B.V. All rights reserved.