PERspective on PER phosphorylation

被引：20

作者：

Blau, Justin ^{[1
]}

机构：

[1] NYU, Dept Biol, New York, NY 10003 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 13期

关键词：

circadian rhythms; Drosophila; PER; beta-TrCP/SLIMB; CK1; epsilon/DBT; F-box protein; phosphorylation;

D O I：

10.1101/gad.1696408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (pp. 1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

引用

收藏

页码：1737 / 1740

页数：4

相关论文

共 27 条

[1] A novel C-terminal domain of Drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription [J].

Chang, DC ;

Reppert, SM .

CURRENT BIOLOGY, 2003, 13 (09) :758-762

[2] The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock [J].

Chiu, Joanna C. ;

Vanselow, Jens T. ;

Kramer, Achim ;

Edery, Isaac .

GENES & DEVELOPMENT, 2008, 22 (13) :1758-1772

[3] TEMPORAL PHOSPHORYLATION OF THE DROSOPHILA PERIOD PROTEIN [J].

EDERY, I ;

ZWIEBEL, LJ ;

DEMBINSKA, ME ;

ROSBASH, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2260-2264

[4] An opposite role for tau in circadian rhythms revealed by mathematical modeling [J].

Gallego, Monica ;

Eide, Erik J. ;

Woolf, Margaret F. ;

Virshup, David M. ;

Forger, Daniel B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (28) :10618-10623

[5] The F-box protein Slimb controls the levels of clock proteins Period and Timeless [J].

Grima, B ;

Lamouroux, A ;

Chélot, E ;

Papin, C ;

Limbourg-Bouchon, B ;

Rouyer, F .

NATURE, 2002, 420 (6912) :178-182

[6]

Hall JC, 2007, COLD SH Q B, V72, P215

[7] The circadian timekeeping system of Drosophila [J].

Hardin, PE .

CURRENT BIOLOGY, 2005, 15 (17) :R714-R722

[8] Posttranscriptional and posttranslational regulation of clock genes [J].

Harms, E ;

Kivimäe, S ;

Young, MW ;

Saez, L .

JOURNAL OF BIOLOGICAL RHYTHMS, 2004, 19 (05) :361-373

[9] A clockwork web: Circadian timing in brain and periphery, in health and disease [J].

Hastings, MH ;

Reddy, AB ;

Maywood, ES .

NATURE REVIEWS NEUROSCIENCE, 2003, 4 (08) :649-661

[10] Familial advanced sleep-phase syndrome:: A short-period circadian rhythm variant in humans [J].

Jones, CR ;

Campbell, SS ;

Zone, SE ;

Cooper, F ;

DeSano, A ;

Murphy, PJ ;

Jones, B ;

Czajkowski, L ;

Ptácek, LJ .

NATURE MEDICINE, 1999, 5 (09) :1062-1065