Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis

被引：250

作者：

Zabel, Brian A. ^{[1
,2
]}

Nakae, Susumu

Zuniga, Luis ^{[1
,2
]}

Kim, Ji-Yun ^{[1
,2
]}

Ohyama, Takao ^{[1
,2
]}

Alt, Carsten ^{[1
,2
]}

Pan, Junliang ^{[1
,2
]}

Suto, Hajime

Soler, Dulce ^{[3
]}

Allen, Samantha J. ^{[4
]}

Handel, Tracy M. ^{[4
]}

Song, Chang Ho ^{[5
]}

Galli, Stephen J. ^{[1
,6
]}

Butcher, Eugene C. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

[2] Vet Affairs Palo Alto Hlth Care Syst, Ctr Mol Biol & Med, Palo Alto, CA 94304 USA

[3] Millennium Pharmaceut Inc, Inflammat Dept, Cambridge, MA 02139 USA

[4] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

[5] Chonbuk Natl Univ, Sch Med, Dept Anat, Jeonju, South Korea

[6] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1084/jem.20080300

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells contribute importantly to both protective and pathological IgE-dependent immune responses. We show that the mast cell-expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell-dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. We further identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. In contrast to other "silent" or professional chemokine interreceptors, chemerin binding does not trigger ligand internalization. Rather, CCRL2 is able to bind the chemoattractant and increase local concentrations of bioactive chemerin, thus providing a link between CCRL2 expression and inflammation via the cell-signaling chemerin receptor CMKLR1.

引用

页码：2207 / 2220

页数：14

共 49 条

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