Prothrombotic activation of pulmonary arterial endothelial cells in a patient with tuberculosis

被引:13
作者
Lang, IM
Mackman, N
Kriett, JM
Moser, KM
Schleef, RR
机构
[1] Scripps Res Inst, DEPT VASC BIOL VB 1, DEPT IMMUNOL, RES INST, LA JOLLA, CA 92037 USA
[2] UNIV CALIF SAN DIEGO, DIV CARDIOTHORAC SURG, SAN DIEGO, CA USA
[3] UNIV CALIF SAN DIEGO, DIV PULM & CRIT CARE MED, SAN DIEGO, CA USA
关键词
vascular endothelium; plasminogen inactivators; thromboplastin;
D O I
10.1016/S0046-8177(96)90118-5
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Activation of endothelial cells occurs in response to numerous physiological stimuli and results in the concerted expression of endothelial cell proteins that change the nonthrombogenic intimal surface of a vessel into a thrombogenic surface, with the subsequent develop ment of local thrombosis. For example, both type 1 plasminogen activator inhibitor and tissue factor expression are mediated by endothelial cell stimulation in vitro; however, in contrast to type 1 plasminogen activator inhibitor, it has been difficult to detect tissue factor associated with endothelial cells in vivo. This case study describes the presence of both type 1 plasminogen activator inhibitor and tissue factor antigen associated with pulmonary arterial endothelial cells of a patient exhibiting a mycobacterial infection. The disease was associated with chronic hemoptysis and characterized by extensive tissue destruction and local thrombosis within the pulmonary artery. The data show that conditions occur in vivo in which local thrombosis is associated with increased levels of type 1 plasminogen activator inhibitor and tissue factor. (C) 1996 by W.B. Saunders Company
引用
收藏
页码:423 / 427
页数:5
相关论文
共 53 条
[31]   IMMUNOHISTOCHEMICAL STUDY OF TISSUE FACTOR EXPRESSION IN NORMAL INTESTINE AND IDIOPATHIC INFLAMMATORY BOWEL-DISEASE [J].
MORE, L ;
SIM, R ;
HUDSON, M ;
DHILLON, AP ;
POUNDER, R ;
WAKEFIELD, AJ .
JOURNAL OF CLINICAL PATHOLOGY, 1993, 46 (08) :703-708
[32]  
MULDER AB, 1994, BLOOD, V84, P1559
[33]   2 DIFFERENT MECHANISMS IN PATIENTS WITH VENOUS THROMBOSIS AND DEFECTIVE FIBRINOLYSIS - LOW CONCENTRATION OF PLASMINOGEN-ACTIVATOR OR INCREASED CONCENTRATION OF PLASMINOGEN-ACTIVATOR INHIBITOR [J].
NILSSON, IM ;
LJUNGNER, H ;
TENGBORN, L .
BRITISH MEDICAL JOURNAL, 1985, 290 (6480) :1453-1456
[34]   PLASMINOGEN-ACTIVATOR INHIBITOR-1 IS INDUCED IN MIGRATING ENDOTHELIAL-CELLS [J].
PEPPER, MS ;
SAPPINO, AP ;
MONTESANO, R ;
ORCI, L ;
VASSALLI, JD .
JOURNAL OF CELLULAR PHYSIOLOGY, 1992, 153 (01) :129-139
[35]  
ROOK GA, 1989, CLIN EXP IMMUNOL, V76, P240
[36]  
RUGGERI ZM, 1981, BLOOD, V57, P1140
[37]   VARIANT VONWILLEBRANDS DISEASE - CHARACTERIZATION OF 2 SUBTYPES BY ANALYSIS OF MULTIMERIC COMPOSITION OF FACTOR 8 VONWILLEBRAND-FACTOR IN PLASMA AND PLATELETS [J].
RUGGERI, ZM ;
ZIMMERMAN, TS .
JOURNAL OF CLINICAL INVESTIGATION, 1980, 65 (06) :1318-1325
[38]  
RYAN J, 1992, BLOOD, V80, P966
[39]   MESSENGER-RNA FOR PLASMINOGEN-ACTIVATOR INHIBITOR [J].
SAWDEY, M ;
NY, T ;
LOSKUTOFF, DJ .
THROMBOSIS RESEARCH, 1986, 41 (02) :151-160
[40]   REGULATION OF MURINE TYPE-1 PLASMINOGEN-ACTIVATOR INHIBITOR GENE-EXPRESSION INVIVO - TISSUE-SPECIFICITY AND INDUCTION BY LIPOPOLYSACCHARIDE, TUMOR-NECROSIS-FACTOR-ALPHA, AND TRANSFORMING GROWTH-FACTOR-BETA [J].
SAWDEY, MS ;
LOSKUTOFF, DJ .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (04) :1346-1353