Transcriptional Modulator NusA Interacts with Translesion DNA Polymerases in Escherichia coli

被引：51

作者：

Cohen, Susan E. ^{[1
]}

Godoy, Veronica G. ^{[2
]}

Walker, Graham C. ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] Northeastern Univ, Dept Biol, Boston, MA 02115 USA

来源：

JOURNAL OF BACTERIOLOGY | 2009年 / 191卷 / 02期

关键词：

PROKARYOTIC RNA-POLYMERASES; ELONGATION-FACTOR NUSA; Y-FAMILY; BACTERIOPHAGE-LAMBDA; REPLICATION BYPASS; SOS MUTAGENESIS; UV MUTAGENESIS; DINB GENE; IN-VITRO; PROTEIN;

D O I：

10.1128/JB.00941-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

NusA, a modulator of RNA polymerase, interacts with the DNA polymerase DinB. An increased level of expression of dinB or umuDC suppresses the temperature sensitivity of the nusA11 strain, requiring the catalytic activities of these proteins. We propose that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polymerases stalled at gaps, coupling TLS to transcription.

引用

收藏

页码：665 / 672

页数：8

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