Regulatory T cells (Treg) in rheumatoid arthritis

被引：95

作者：

Boissier, Marie-Christophe ^{[1
,2
,3
]}

Assier, Eric ^{[1
,2
,3
]}

Biton, Jerome ^{[1
,2
,3
]}

Denys, Anne ^{[1
,2
,3
]}

Falgarone, Geraldine ^{[1
,2
,3
]}

Bessis, Natacha ^{[1
,2
,3
]}

机构：

[1] CHU Avicenne, Serv Rhumatol, AP HP, F-93009 Bobigny, France

[2] INSERM, ER118, Bobigny, France

[3] Univ Paris 13, EA4222, F-93430 Villetaneuse, France

来源：

JOINT BONE SPINE | 2009年 / 76卷 / 01期

关键词：

T lymphocytes; Rheumatoid arthritis; Immunomodulation; Cytokines; Cell therapy; Regulatory T lymphocytes; COLLAGEN-INDUCED ARTHRITIS; PERIPHERAL-BLOOD; AUTOIMMUNE-DISEASES; SYNOVIAL-FLUID; IN-VIVO; FOXP3; SUPPRESSION; INDUCTION; TOLERANCE; EXPANSION;

D O I：

10.1016/j.jbspin.2008.08.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Modulation of the T-cell response depends chiefly on regulatory T cells (Treg), which express CD4 and CD25. Some Treg cells are present naturally, whereas others are induced in response to antigens. The immunomodulating effects of Treg cells are mediated by membrane molecules (e.g., CTLA4, GITR, and OX40) and cytokines. IL-35 seems to be a crucial mediator, although IL-10 and TGF beta are also important. The role for Treg cells in rheumatoid arthritis (RA) has been established in both patients and animal models. Treg function is deficient in RA, whereas Treg counts vary. Treg counts increase in patients who are responding to TNF alpha antagonist therapy. Among current hypotheses, Treg expansion or transfer may hold promise for the treatment of RA. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：10 / 14

页数：5

共 32 条

[21] CD25+cell depletion hastens the onset of severe disease in collagen-induced arthritis
Morgan, ME
Sutmuller, RPM
Witteveen, HJ
van Duivenvoorde, LM
Zanelli, E
Melief, CJM
Snijders, A
Offringa, R
de Vries, RRP
Toes, REM
[J]. ARTHRITIS AND RHEUMATISM, 2003, 48 (05): : 1452 - 1460
[22] CD4+ CD25+ T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
Möttönen, M
Heikkinen, J
Mustonen, L
Isomäki, P
Luukkainen, R
Lassila, O
[J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2005, 140 (02) : 360 - 367
[23] Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis
Nguyen, Linh T.
Jacobs, Jonathan
Mathis, Diane
Benoist, Christophe
[J]. ARTHRITIS AND RHEUMATISM, 2007, 56 (02): : 509 - 520
[24] SAKAGUCHI S, 1995, J IMMUNOL, V155, P1151
[25] B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
Salomon, B
Lenschow, DJ
Rhee, L
Ashourian, N
Singh, B
Sharpe, A
Bluestone, JA
[J]. IMMUNITY, 2000, 12 (04) : 431 - 440
[26] Suri-Payer E, 1998, J IMMUNOL, V160, P1212
[27] In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
Tang, QZ
Henriksen, KJ
Bi, MY
Finger, EB
Szot, G
Ye, JQ
Masteller, EL
McDevitt, H
Bonyhadi, M
Bluestone, JA
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (11) : 1455 - 1465
[28] TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
Valencia, X
Stephens, G
Goldbach-Mansky, R
Wilson, M
Shevach, EM
Lipsky, PE
[J]. BLOOD, 2006, 108 (01) : 253 - 261
[29] CD4+CD25+ regulatory T cells in rheumatoid arthritis - Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
van Amelsfort, JMR
Jacobs, KMG
Bijlsma, JWJ
Lafeber, FPJG
Taams, LS
[J]. ARTHRITIS AND RHEUMATISM, 2004, 50 (09): : 2775 - 2785
[30] Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
van Amelsfort, Jocea M. R.
van Roon, Joel A. G.
Noordegraaf, Madelon
Jacobs, Kim M. G.
Bijlsma, Johannes W. J.
Lafeber, Floris P. J. G.
Taams, Leonie S.
[J]. ARTHRITIS AND RHEUMATISM, 2007, 56 (03): : 732 - 742

← 1 2 3 4 →