Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome

被引：20

作者：

Ondo, William G. ^{[1
]}

Jankovic, Joseph ^{[2
]}

Simpson, Richard ^{[3
]}

Jimenez-Shahed, Joohi ^{[2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, Houston, TX USA

[2] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[3] Methodist Neurosci Inst, Dept Neurosurg, Houston, TX USA

来源：

SLEEP MEDICINE | 2012年 / 13卷 / 09期

关键词：

Restless legs syndrome; Deep brain stimulation; Globus pallidus internus; Neurophysiology; DBS; Surgery; SUBTHALAMIC STIMULATION; PARKINSONS-DISEASE; IMPROVE;

D O I：

10.1016/j.sleep.2012.06.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The neuroanatomic substrate of restless legs syndrome (RLS) is unknown. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) and other targets is used to treat Parkinson's disease (PD), and RLS symptoms associated with PD have been reported to improve when GPi DBS is used in that population. We wish to test whether GPi DBS can improve idiopathic RLS. Method: We implanted bilateral GPi DBS in a subject with refractory idiopathic RLS. Results: The GPi cells recordings were dissimilar to those of PD. Clinically, the patient had a good, but far from complete, response, which more prominently affected the urge to move and involuntary movements than the painful component. Conclusion: DBS for RLS remains investigational. (C) 2012 Published by Elsevier B.V.

引用

页码：1202 / 1204

页数：3

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