Regulation by destruction: design of the σE envelope stress response

被引：137

作者：

Ades, Sarah E. ^{[1
]}

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2008年 / 11卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.mib.2008.10.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The signal transduction pathway governing the sigma(E)-dependent cell envelope stress response in Escherichia coli communicates information from the periplasm to sigma(E) in the cytoplasm via a regulated proteolytic cascade that results in the destruction of the membrane-bound antisigma factor, RseA, and the release of sigma(E) to direct transcription. Regulated proteolysis is used for signal transduction in all domains of life, and these pathways bear remarkable similarities in their architecture and the proteases involved. Work with the pathway governing the sigma(E) response has elucidated key design principles that ensure a rapid yet graded response that is buffered from inappropriate activation. Structural and biochemical studies of the proteases that mediate signal transduction reveal the molecular underpinnings enabling this design.

引用

页码：535 / 540

页数：6

共 46 条

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