Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines

被引：83

作者：

Aizenman, CD ^{[1
]}

Muñoz-Elías, G ^{[1
]}

Cline, HT ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NEURON | 2002年 / 34卷 / 04期

关键词：

D O I：

10.1016/S0896-6273(02)00674-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ca2+-permeable AMPARs are inwardly rectifying due to block by intracellular polyamines. Neuronal activity regulates polyamine synthesis, yet whether this affects Ca2+-AMPAR-mediated synaptic transmission is unknown. We test whether 4 hr of increased visual stimulation regulates glutamatergic retino-tectal synapses in Xenopus tadpoles. Tectal neurons containing Ca2+-AMPARs form a gradient along the rostro-caudal developmental axis. These neurons had inwardly rectifying AMPAR-mediated EPSCs. Four hours of visual stimulation or addition of intracellular spermine increased rectification in immature neurons. Polyamine synthesis inhibitors blocked the effect of visual stimulation, suggesting that visual activity regulates AMPARs via the polyamine synthesis pathway. This modulation resulted in changes in the integrative properties of tectal neurons. Regulation of polyamine synthesis by physiological stimuli is a novel form of modulation of synaptic transmission important for understanding the short-term effects of enhanced sensory experience during development.

引用

页码：623 / 634

页数：12

共 62 条

[1] Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation [J].

Barria, A ;

Muller, D ;

Derkach, V ;

Griffith, LC ;

Soderling, TR .

SCIENCE, 1997, 276 (5321) :2042-2045

[2] KAINATE-INDUCED SEIZURE ACTIVITY STIMULATES THE POLYAMINE INTERCONVERSION PATHWAY IN RAT-BRAIN [J].

BAUDRY, M ;

NAJM, I .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :151-154

[3] SUBUNIT COMPOSITION AT THE SINGLE-CELL LEVEL EXPLAINS FUNCTIONAL-PROPERTIES OF A GLUTAMATE-GATED CHANNEL [J].

BOCHET, P ;

AUDINAT, E ;

LAMBOLEZ, B ;

CREPEL, F ;

ROSSIER, J ;

IINO, M ;

TSUZUKI, K ;

OZAWA, S .

NEURON, 1994, 12 (02) :383-388

[4]

Bollmann JH, 1998, J NEUROSCI, V18, P10409

[5] INWARD RECTIFICATION OF BOTH AMPA AND KAINATE SUBTYPE GLUTAMATE RECEPTORS GENERATED BY POLYAMINE-MEDIATED ION-CHANNEL BLOCK [J].

BOWIE, D ;

MAYER, ML .

NEURON, 1995, 15 (02) :453-462

[6]

Bowie D, 1998, J NEUROSCI, V18, P8175

[7] Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues [J].

Burnashev, N ;

Villarroel, A ;

Sakmann, B .

JOURNAL OF PHYSIOLOGY-LONDON, 1996, 496 (01) :165-173

[8] CALCIUM-PERMEABLE AMPA-KAINATE RECEPTORS IN FUSIFORM CEREBELLAR GLIAL-CELLS [J].

BURNASHEV, N ;

KHODOROVA, A ;

JONAS, P ;

HELM, PJ ;

WISDEN, W ;

MONYER, H ;

SEEBURG, PH ;

SAKMANN, B .

SCIENCE, 1992, 256 (5063) :1566-1570

[9] Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo [J].

Cantallops, I ;

Haas, K ;

Cline, HT .

NATURE NEUROSCIENCE, 2000, 3 (10) :1004-1011

[10] Regulation of AMPA receptors by phosphorylation [J].

Carvalho, AL ;

Duarte, CB ;

Carvalho, AP .

NEUROCHEMICAL RESEARCH, 2000, 25 (9-10) :1245-1255

← 1 2 3 4 5 6 7 →