The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?

被引：138

作者：

Qvist, Per ^{[1
]}

Bay-Jensen, Anne-Christine ^{[1
]}

Christiansen, Claus ^{[1
]}

Dam, Erik B. ^{[1
]}

Pastoureau, Philippe ^{[2
]}

Karsdal, Morten A. ^{[1
]}

机构：

[1] Nord Biosci AS, DK-2730 Herlev, Denmark

[2] Inst Rech Servier, F-92150 Suresnes, France

来源：

PHARMACOLOGICAL RESEARCH | 2008年 / 58卷 / 01期

关键词：

DMOAD; osteoarthritis; treatment;

D O I：

10.1016/j.phrs.2008.06.001

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Till date, the pharmaceutical industry has failed to bring effective and safe disease modifying osteoarthritic drugs (DMOADs) to the millions of patients suffering from this serious and deliberating disease. We provide a review of recent data reported on the investigation of DMOADs in clinical trials, including compounds inhibiting matrix-metalloproteinases (MMPs), bisphos phonates, cytokine blockers, calcitonin, inhibitors of inducible nitric oxide synthase (NOS), doxycycline, glucosamine, and diacereine. We discuss the challenges associated with the drug development process in general and with DMOADs in particular, and we advance the need for a new development paradigm for DMOADs. Two central elements in this paradigm are a stronger focus on the biology of the joint and the application of new and more sensitive biomarkers allowing redesign of clinical trials in osteoarthritis. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1 / 7

页数：7

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