Nitric oxide donors: Chemical activities and biological applications

被引：1201

作者：

Wang, PG ^{[1
]}

Xian, M ^{[1
]}

Tang, XP ^{[1
]}

Wu, XJ ^{[1
]}

Wen, Z ^{[1
]}

Cai, TW ^{[1
]}

Janczuk, AJ ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 04期

关键词：

D O I：

10.1021/cr000040l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the past decade, hundreds of NO donors have been developed and widely used in biological research. The current development of NO donors includes discovery of new donors, finding novel applications for NO donors, development of NO-drug hybrids, and development of NO donors with good tissue specificity. Among these four fields, the development of NO donors with good tissue specificity is the most challenging work for chemists and biochemists. The problem is related to the ubiquity of NO itself in the body.

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页码：1091 / 1134

页数：44

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