Mechanisms of Obesity-Induced Gastrointestinal Neoplasia

被引：198

作者：

Aleman, Jose O. ^{[1
]}

Eusebi, Leonardo H. ^{[2
]}

Ricciardiello, Luigi ^{[2
,3
]}

Patidar, Kavish ^{[4
]}

Sanyal, Arun J. ^{[4
]}

Holt, Peter R. ^{[1
]}

机构：

[1] Rockefeller Univ, Biochem Genet & Metab Lab, New York, NY 10065 USA

[2] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy

[3] Univ Bologna, Ctr Appl Biomed Res, Bologna, Italy

[4] Virginia Commonwealth Univ, Sch Med, Richmond, VA USA

来源：

GASTROENTEROLOGY | 2014年 / 146卷 / 02期

关键词：

Colorectal Cancer; Esophageal Cancer; Gastric Cancer; Pancreatic Cancer; BODY-MASS INDEX; GROWTH-FACTOR-I; COLORECTAL-CANCER RISK; SOLUBLE LEPTIN RECEPTOR; ESOPHAGEAL ADENOCARCINOMA CELLS; HIGH-FAT DIET; HUMAN PANCREATIC-CANCER; ABERRANT CRYPT FOCI; ADIPOSE-TISSUE; COLON-CANCER;

D O I：

10.1053/j.gastro.2013.11.051

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and associated disorders, including gastrointestinal cancers, have high morbidity and mortality. An increased understanding of the mechanisms of obesity-induced carcinogenesis is required to develop methods to prevent or treat these cancers. In this report, we review the mechanisms of obesity-associated colorectal, esophageal, gastric, and pancreatic cancers and potential treatment strategies.

引用

页码：357 / 373

页数：17

共 234 条

[1]

A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma [J].

Abnet, Christian C. ;

Freedman, Neal D. ;

Hollenbeck, Albert R. ;

Fraumeni, Joseph F., Jr. ;

Leitzmann, Michael ;

Schatzkin, Arthur .

EUROPEAN JOURNAL OF CANCER, 2008, 44 (03) :465-471

[2]

Long-term mortality after gastric bypass surgery [J].

Adams, Ted D. ;

Gress, Richard E. ;

Smith, Sherman C. ;

Halverson, R. Chad ;

Simper, Steven C. ;

Rosamond, Wayne D. ;

LaMonte, Michael J. ;

Stroup, Antoinette M. ;

Hunt, Steven C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) :753-761

[3]

Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition Cohort [J].

Aleksandrova, Krasimira ;

Boeing, Heiner ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Jansen, Eugene ;

van Duijnhoven, Franzel J. B. ;

Rinaldi, Sabina ;

Fedirko, Veronika ;

Romieu, Isabelle ;

Riboli, Elio ;

Gunter, Marc J. ;

Westphal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Halkjaer, Jytte ;

Racine, Antoine ;

Boutron-Ruault, Marie-Christine ;

Clavel-Chapelon, Francoise ;

Kaaks, Rudolf ;

Lukanova, Annekatrin ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Mattiello, Amalia ;

Pala, Valeria ;

Palli, Domenico ;

Tumino, Rosario ;

Vineis, Paolo ;

Buckland, Genevieve ;

Sanchez, Maria-Jose ;

Amiano, Pilar ;

Maria Huerta, Jose ;

Barricarte, Aurelio ;

Menendez, Virginia ;

Peeters, Petra H. ;

Soderberg, Stefan ;

Palmqvist, Richard ;

Allen, Naomi E. ;

Crowe, Francesca L. ;

Khaw, Kay-Tee ;

Wareham, Nickolas ;

Pischon, Tobias .

CANCER RESEARCH, 2012, 72 (20) :5328-5337

[4]

Total and high-molecular weight adiponectin and risk of colorectal cancer: the European Prospective Investigation into Cancer and Nutrition Study [J].

Aleksandrova, Krasimira ;

Boeing, Heiner ;

Jenab, Mazda ;

Bueno-de-Mesquita, H. Bas ;

Jansen, Eugene ;

van Duijnhoven, Franzel J. B. ;

Fedirko, Veronika ;

Rinaldi, Sabina ;

Romieu, Isabelle ;

Riboli, Elio ;

Romaguera, Dora ;

Westphal, Sabine ;

Overvad, Kim ;

Tjonneland, Anne ;

Boutron-Ruault, Marie Christine ;

Clavel-Chapelon, Francoise ;

Kaaks, Rudolf ;

Lukanova, Annekatrin ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Agnoli, Claudia ;

Mattiello, Amalia ;

Saieva, Calogero ;

Vineis, Paolo ;

Tumino, Rosario ;

Peeters, Petra H. ;

Argueelles, Marcial ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Dorronsoro, Miren ;

Huerta, Jose-Maria ;

Barricarte, Aurelio ;

Palmqvist, Richard ;

Hallmans, Goran ;

Khaw, Kay-Tee ;

Wareham, Nick ;

Allen, Naomi E. ;

Crowe, Francesca L. ;

Pischon, Tobias .

CARCINOGENESIS, 2012, 33 (06) :1211-1218

[5]

Expression of microRNAs: potential molecular link between obesity, diabetes and cancer [J].

Ali, A. S. ;

Ali, S. ;

Ahmad, A. ;

Bao, B. ;

Philip, P. A. ;

Sarkar, F. H. .

OBESITY REVIEWS, 2011, 12 (12) :1050-1062

[6]

Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study [J].

Anderson, Lesley A. ;

Watson, R. G. Peter ;

Murphy, Seamus J. ;

Johnston, Brian T. ;

Comber, Harry ;

Mc Guigan, Jim ;

Reynolds, John V. ;

Murray, Liam J. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (10) :1585-1594

[7]

[Anonymous], J CLIN ONCOL

[8]

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota [J].

Arthur, Janelle C. ;

Perez-Chanona, Ernesto ;

Muehlbauer, Marcus ;

Tomkovich, Sarah ;

Uronis, Joshua M. ;

Fan, Ting-Jia ;

Campbell, Barry J. ;

Abujamel, Turki ;

Dogan, Belgin ;

Rogers, Arlin B. ;

Rhodes, Jonathan M. ;

Stintzi, Alain ;

Simpson, Kenneth W. ;

Hansen, Jonathan J. ;

Keku, Temitope O. ;

Fodor, Anthony A. ;

Jobin, Christian .

SCIENCE, 2012, 338 (6103) :120-123

[9]

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways [J].

Attoub, S ;

Noe, V ;

Pirola, L ;

Bruyneel, E ;

Chastre, E ;

Mareel, M ;

Wymann, MP ;

Gespach, C .

FASEB JOURNAL, 2000, 14 (14) :2329-2338

[10]

The gut microbiota as an environmental factor that regulates fat storage [J].

Bäckhed, F ;

Ding, H ;

Wang, T ;

Hooper, LV ;

Koh, GY ;

Nagy, A ;

Semenkovich, CF ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723

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