Lembehyne A, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell

被引：31

作者：

Aoki, S ^{[1
]}

Matsui, K ^{[1
]}

Takata, T ^{[1
]}

Hong, W ^{[1
]}

Kobayashi, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 289卷 / 02期

关键词：

lembehyne A; neuronal differentiation; Neuro 2A cells; G1; arrest;

D O I：

10.1006/bbrc.2001.6012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lembehyne A (LB-A), a spongean polyacetylene, induced neuronal cell differentiation in a neuroblastoma cell line, Neuro 2A. The LB-A treatment of Neuro 2A cells predominantly resulted in a morphological change with bipolar neurites. The acetylcholinesterase activity of Neuro 2A was also increased by the treatment of LB-A. Furthermore, the cell cycle of Neuro, 2A cells was found to be specifically blocked at the G1 phase by LB-A. The structure-activity relationship study using the LB-A analogues revealed the importance of the terminal 1-yn-3-ol and unsaturated long-chain alkyl moieties for the neuronal differentiation activity of LB-A. (C) 2001 Elsevier Science.

引用

页码：558 / 563

页数：6

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