The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

被引：634

作者：

Hamaratoglu, F

Willecke, M

Kango-Singh, M

Nolo, R

Hyun, E

Tao, CY

Jafar-Nejad, H

Halder, G ^{[1
]}

机构：

[1] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[3] Univ Tubingen, Interfak Inst Zellbiol, Abt Genet Tiere, D-72076 Tubingen, Germany

[4] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[5] Univ Texas, MD Anderson Canc Ctr, Program Genes & Dev, Houston, TX 77030 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ncb1339

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Merlin, the protein product of the Neurofibromatosis type- 2 gene, acts as a tumour suppressor in mice and humans. Merlin is an adaptor protein with a FERM domain and it is thought to transduce a growth- regulatory signal. However, the pathway through which Merlin acts as a tumour suppressor is poorly understood. Merlin, and its function as a negative regulator of growth, is conserved in Drosophila, where it functions with Expanded, a related FERM domain protein. Here, we show that Drosophila Merlin and Expanded are components of the Hippo signalling pathway, an emerging tumour- suppressor pathway. We find that Merlin and Expanded, similar to other components of the Hippo pathway, are required for proliferation arrest and apoptosis in developing imaginal discs. Our genetic and biochemical data place Merlin and Expanded upstream of Hippo and identify a pathway through which they act as tumour- suppressor genes.

引用

页码：27 / U9

页数：13

共 49 条

[1] Cell proliferation, survival, and death in the Drosophila eye [J].